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This occurred every day after his morning dose and lasted for a few hours Celebrex is a COX II Inhibitor are a fairly new class of NSAIDS. The postoperative use of celecoxib did not increase range of motion or subjective outcome 1 year after TKR. The pain-relieving effects of Celebrex last for approximately 12 hours. However to be safe some surgeons recommend to stop Celebrex 7 to 10 days before surgery. It can take up to a year for any leg swelling to disappear. But because of CV risk, Vioxx got withdrawn from the market and Celebrex got black-boxed. Should I still have pain 8 weeks after knee replacement? Half the patients were treated with 300 milligrams of Lyrica two hours before surgery and 150. Confusion arises because in studies Celebrex does not cause increased bleeding. The study involved 240 patients undergoing knee replacement surgery who were divided into two groups. I guess I didn't hit the right buttons Friday when I answered you. 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