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Use the medicine before going to bed and leave it on for 8 hours. 2) My understanding is that treatment should be withheld from overtly inflamed tissue, until it heals. In clinical studies, Aldara ( imiquimod) topical cream was found to completely clear external genital warts in 50% of patients who applied treatment 3 days a week for a total of 16 weeks. Sufficient cream should be applied to cover the area and 1cm of skin surrounding the lesion: Genital warts : The patient should apply imiquimod cream once daily at bedtime, three times a week (e. 3) I can't say whether these or other treatments might prevent discoloration. 5% cream: Apply 2 times per week prior to normal sleeping hours, to a treatment area. I have read elsewhere to only apply to the warts, but i have also read that aldara seems to respect healthy skin and only attacks unhealthy skin. Examples of 3 times per week application schedules are: Monday, Wednesday, Friday or Tuesday, Thursday. 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